McCullen is introduced in the film as a philanthropic scientist and businessman who is head of M.A.R.S. He was portrayed by Christopher Eccleston, who also played Raymond Calitri in Gone in 60 Seconds, Henry West in 28 Days Later and, Malekith the Accursed in Thor: The Dark World. Industries, however later on Rex Lewis originally known as "The Doctor" wrests control of the organization from him and assumes the title of "Cobra Commander" renaming it COBRA. Joe: The Rise of Cobra and a minor antagonist of G.I. Joe film series, serving as one of the two main antagonists (along with Cobra Commander) of G.I. Laird James McCullen, also later known as Destro, is a recurring antagonist of the G.I.
~ McCullen revealing his plan to the Doctor. You'll be able to do all the research you want. When I'm finished, the money will take care of its self. When these missiles detonate, the world will turn to the most powerful man on the planet. It has to be taken out of chaos by someone with complete control.
What it needs is unification, leadership.
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